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The title of my PhD thesis is "Spectroscopic and molecular dynamics studies of fibrillar protein aggregates".
This research is aimed at elucidating the mechanisms of interactions between the novel cyanine dyes and amyloid fibrils using fluorescence and absorption spectroscopy,
and molecular dynamics simulations. More specifically, my goals are: determination of the quantitative characteristics of the
dye binding to lysozyme and insulin amyloid fibrils, selection of the most sensitive amyloid markers, development of the novel method for amyloid
detection based on the cyanine H- and J-aggregates formation on the fibril surface, and molecular dynamics simulations of the effects of amyloidogenic
mutations on the protein stability.
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