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Homepage of Valeriya Trusova

Valeriya M.
Trusova (Ioffe)



My thesis "Lysozyme interactions with model membranes" is focused on versatile characterization of lysozyme-lipid complexes with a range of fluorescence spectroscopy techniques. Such studies seem to be of great interest because biological functions of lysozyme including antimicrobial, antitumor and immune modulatory activites may be related not only to the ability of this enzyme to hydrolyze peptidoglycan layer of bacterial cell wall, but also to its lipid binding properties. We found that conformation, extent of bilayer penetration and orientation of membrane-bound lysozyme favor its self-association in a membrane environment. Both electrostatic and hydrophobic protein-lipid interactions are hypothesized to control the aggregation behavior of lysozyme. Modulation of lysozyme aggregation propensity by membrane binding may have important implications for protein fibrillogenesis in vivo. Disruption of membrane integrity by the aggregated lysozyme species may be responsible for their cytotoxicity.
VI European Biophysics Congress, London, 2007 International Symposium on Organic Chemistry, Sofia, 2006
Right: Professor Todor Deligeorgiev from Sofia University "St. Kliment Ohridski"

10th Conference on Methods and Applications in Fluorescence, Salzburg, 2007

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